COMPLETE BLOOD COUNT (CBC) **

Effective Date: 
Fri, 02/01/2019
Revised: 
Tue, 01/29/2019
Policy: 

 

Principle

The Sysmex XN-450/XN-430 is a quantitative automated hematology analyzer for in vitro diagnostic use in determining 23 whole blood diagnostic parameters (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, RDW-SD, RDW-CV, MPV, NEUT#, LYMPH#, MONO#, EO#, BASO#, IG#, NEUT%, LYMPH%, MONO%, EO%,BASO%, IG%).  Examination of the numerical and/or morphological findings of the complete blood count by the physician are useful in the diagnosis of disease states such as anemias, leukemias, allergic reactions, viral, bacterial, and parasitic infections.

This device performs hematology analyses based on the hydrodynamically focused impedance measurement, the flow cytometry method (using a semiconductor laser) and the SLS-hemoglobin method.

The device counts and sizes red blood cells (RBC) and platelets (PLT) using hydrodynamic impedance counting.  At the same time the hematocrit (HCT) is calculated via the RBC pulse height detection method.   Cytometry is used to analyze physiological and chemical characteristics of cells and other biological particles. Flow cytometry is a method used to analyze those cells and particles as they pass through extremely small flow cells.

Specimen Collection and Handling

WARNING:  All patient specimens should be considered potentially infectious and must be handled with precautions used for human blood, as described in CDC recommendations and in compliance with the Federal OSHA Bloodborne Pathogen Standard, 29CFR part 1910.1030.  Follow specimen handling as outlined by laboratory safety policy.

Recommended:   Wear gloves and a lab coat.  Wear safety glasses if there is a risk of splashing.

A. Required specimen

  1.  Whole blood should be collected in EDTA-2K or EDTA-3K anticoagulant.

B.  Specimen volumes required

  1. Optimal draw is a 13 x 75 tube filled to capacity
  2. A minimum of 1 mL whole blood is required for sample analysis
  3. Manual analysis whole blood mode
  • Closed tube – 1 mL
  • Open tube – 300 μL

C.  Unacceptable specimens including those listed below must be redrawn:

  • Clotted samples or those containing clots, fibrin strands, or platelet clumps.  All specimens will be checked visually for obvious clots prior to sampling by the analyzer.
  • Grossly hemolyzed samples.
  • Samples drawn above an IV line.

D.  Characteristics that may affect test results: lipemia, icterus, and cold agglutinins.

E.  Stored Specimen Stability

  •  EDTA blood samples should be analyzed within 4 hours.
  • If analysis cannot be performed as instructed in the Sysmex Instructions for Use, store in refrigerator at 2-8°C.
  • Allow refrigerated samples to come to room temperature and mix well before analysis.
  • Do not place CBC and Diff samples on a mechanical rocker.  Constant rocking may alter white cell membranes, resulting in false interpretive messages.

 

SUPPLIES AND REAGENTS

Equipment Performance Parameters
The SYSMEX 430-XN Analyzer has operating parameters of ambient temperature 15-35 deg C,  of humidity 20-85%.

 Reagents 

A.  Supplies

  • Lint-free lab wipes
  • Gauze
  • Test tubes
  • Pipettes
  • CELLCLEAN® AUTO
  • Sysmex reagents
  • Commercial controls: XN-L CHECK TM

B.  Sysmex Reagents

  • Sysmex reagents and CELLCLEAN AUTO are used on all Sysmex XN-L Series modules.
  • All reagents are used at room temperature and are to be used within the manufacturer’s expiration date on each container.
  • Record date received and date opened on container.
  • All reagents are azide free and are intended for in vitro diagnostic use only.  Do not ingest.

              XN-L REAGENTS                                    OPEN EXPIRATION

               CELLPACK DCL                                            60 Days

               SULFOLYSER                                               60 Days (1.5L)

               LYSERCELL WDF                                           90 Days

               FLUOROCELL WDF                                         90 Days

 

C.  Diluents

1.  CELLPACK DCL: Whole blood diluent for use in hematology analyzers.                         CELL PACK STORAGE

  • Store at 2o-35oC away from direct sunlight.
  • If frozen, thaw and mix thoroughly before using.
  • CELLPACK DCL is clear and colorless.  If it is showing signs of contamination or instability such as cloudiness or discoloration, replace container.

                  CELLPACK DCL Stability

  • Unopened, it is stable until expiration date printed on the container.
  • Opened, stable for 60 Days.

                  CELLPACK DCL Hazard Risk

The OSHA Hazard Communication Standard of 29CFR part 1910.1200 requires SDS documentation of ingredients which have been determined to be health hazards, comprise 1% or greater of the composition, are physical hazards, are capable of release to exceed permissible exposure limit/threshold limit values or have been identified as carcinogens.  CELLPACK does not have ingredients with those characteristics.

 

 

 

D.  Lysing Reagents

  1. SULFOLYSER (SLS): Reagent for the automated determination of hemoglobin concentration of blood.  Sulfolyser is lysing reagent that releases the hemoglobin to be measured by the SLS hemoglobin method.

      SULFOLYSER Storage

  • Store at 1o-30oC away from direct sunlight.
  • Allow the container to equilibrate to environmental temperature (15-35o) prior to use.
  • Replace the reagent if it is showing signs of contamination or instability such as cloudiness or discoloration.

         SULFOLYSER Stability

  • Unopened, it is stable until expiration date printed on the container.
  • Opened, stable for 60 Days (1.5L) or 90 Days (5L).

         SULFOLYSER Hazard Risk

The OSHA Hazard Communication Standard of 29CFR part 1910.1200 requires SDS documentation of ingredients which have been determined to be health hazards, comprise 1% or greater of the composition, are physical hazards, are capable of release to exceed permissible exposure limit/threshold limit values or have been identified as carcinogens.  SULFOLYSER does not have ingredients with those characteristics.

 

2. Lysercell WDF: Reagent product to be combined and used with Fluorocell WDF.  By hemolyzing red blood cells with Lysercell WDF and dying the white blood cell component with Fluorocell WDF, the counts and percentages of neutrophils, lymphocytes, monocytes, eosinophils and basophils are analyzed.

         Lysercell WDF Storage

  • Store at 2o-35oC away from direct sunlight.
  • Use at an environmental temperature (15-35o).
  • Do not use the reagent if it is suspected to have frozen.
  • Replace the reagent if it is showing signs of contamination or instability such as cloudiness or discoloration.

        Lysercell WDF Stability

  • Unopened, it is stable until expiration date printed on the container.
  • Opened, stable for 90 Days.

        Lysercell WDF Hazard Risk

The OSHA Hazard Communication Standard of 29CFR part 1910.1200 requires SDS documentation of ingredients which have been determined to be health hazards, comprise 1% or greater of the composition, are physical hazards, are capable of release to exceed permissible exposure limit/threshold limit values or have been identified as carcinogens.  Lysercell WDF does not have ingredients with those characteristics.

E.  Staining Reagents

1.  Fluorocell WDF: Used to stain the leukocytes in diluted and lysed blood samples for determination of differential count in blood.

        Fluorocell WDF Storage

  • Store at 2o-35oC in a dark place.
  • Do not use the reagent if it is suspected to have frozen.
  • Fluorocell WDF Stability
  • Unopened, it is stable until expiration date printed on the container.
  • Opened, stable for 90 Days.

       Fluorocell WDF Hazard Risk

The OSHA Hazard Communication Standard of 29CFR part 1910.1200 requires SDS documentation of ingredients which have been determined to be health hazards, comprise 1% or greater of the composition, are physical hazards, are capable of release to exceed permissible exposure limit/threshold limit values or have been identified as carcinogens.  Refer to the SDS.

F.  Cleaning Agent

CELLCLEAN AUTO: Detergent for fully automated hematology analyzer.  To be used as a strong alkaline detergent to remove lysing reagents, cellular residuals, and blood proteins remaining in the hydraulics of the analyzer on XN series/XN-L series automated hematology analyzers.

         CELLCLEAN AUTO Storage

  • Store at 1-30o C, away from direct sunlight.
  • Do not use the reagent if it is suspected to have frozen.

         CELLCLEAN AUTO Stability

  • Unopened, it is stable until expiration date printed on the container.

         CELLCLEAN AUTO Hazard Risk

     The OSHA Hazard Communication Standard of 29CFR part 1910.1200 requires SDS documentation of ingredients which have been determined to be health hazards, comprise 1% or greater of the composition, are physical hazards, are capable of release to exceed permissible exposure limit/threshold limit values or have been identified as carcinogens.  Refer to the SDS, CELLCLEAN AUTO is corrosive and may cause burns to skin.

G.  Commercial Control Material for XN-430 Analyzers

  1. XN- L CHECK
  • Manufactured by Streck, available as a tri-level package.
  • Whole blood commercial control used to monitor performance of all XN-450/XN-430 analyzer platforms.
  • Formulation
  1.  XN-L CHECK consists of human and/or animal red and white blood cells with a platelet component suspended in fluid medium.
  2. Each vial contains 3 mL of control material.
  • Storage
  1. Store vials at 2-8oC.
  2. Do not freeze or expose to excessive heat.
  • Stability
  1. Unopened and properly stored, XN-L CHECK is stable until the expiration date printed on the unopened vial.
  2. Open vial stability is 15 days for XN-L CHECK  when promptly refrigerated after each use.
  3. Record the date on each vial upon opening or cap piercing.
  4. Heat or freezing can damage XN-L CHECK without gross visible changes.  Moderate hemolysis can be normal.  Deterioration is suspected when the mean of the control results is not within the assay expected ranges after appropriate troubleshooting.
  5. If deterioration is suspected, call the Sysmex Technical Assistance Center.  1-888-879-7639 (1-888-8SYSMEX)

WARNING:    POTENTIALLY INFECTIOUS MATERIAL.

The human blood used in XN-L CHECK is non-reactive for Hepatitis B Surface Antigen and negative for antibodies to HIV-1, HIV-2, and Hepatitis C Virus using FDA specified techniques.  However, no current tests can assure the absence of these pathogens.  XN-L CHECK should be considered potentially infectious and must be handled with precautions used for human blood as described in CDC recommendations and in compliance with the Federal OSHA Bloodborne Pathogen Standard, 29CFR, 1910.1030.

H.  XN-430 Reagent Replacement

  1. When the replacement of reagent is required, an error message appears. Promptly acknowledge the error message by clicking execute to enter the reagent replace dialog box and proceed to replace the indicated reagent. Verify that “CAPS LOCK is off.
  2. Replacing a new diluent / hemolytic agent
  • Touch the name of the reagent to be replaced.
  • Place a check-mark next to ‘Replace the reagent,’ then place the cursor in the reagent code text box. 
  •   Using the hand-held reader, scan the reagent code on the new reagent container. NOTE: Scan Reagent Code 2 which is on the top of the container.
  • Remove the cap from the expired/empty continer and carefully remove the spout.
  • Pull out the dispensing set straight up.
  • Insert the dispensing set straight into the new reagent container and close the cap.
  • Select [Execute]
  • Reagent replacement starts.  When complete, the dialog bos closes automatically.

3.  Replacing Dye

  • Display the [Reagent Replacement] dialog box.
  • Prepare the new reagent cartridge.
  • Confirm the reagent has not expired.
  • Pull out the dye holder drawer.
  • Slowly remove the dye cover, taking care that dye does not drip.
  • Remove the entire dye holder.
  • When the dye holder is removed, a Help dialog box appears in the IPU screen.
  • Remove the old reagent cartridge from its holder.
  • Install the new reagent cartridge into the holder.
  •      Make sure the color of the label on the new reagent cartridge matches the color  of the dye cover and install.  Analyzer will beep as confirmation of new reagent installation.
  •       If the wrong reagent is installed, the analyzer beeps repeatedly and the Help dialog box appears in the IPU screen.
  • Place the dye cover.
  •        Place into dye holder drawer.
  •        The ID of the new reagent is read automatically and the information is registered.
  • Close the dye holder drawer.
  •        Reagent replacement starts.
  •        When complete, the reagent replacement window closes automatically.

PRECISION AND CALIBRATION

The process for checking the accuracy and precision of an analyzer at regular timed intervals is known as calibration verification.  Historically, a calibrator has been used on a semi-annual basis as a "check" of daily QC procedures.  Since our instrument uses a BeyondCare Quality Monitor application, calibration is verified each time QC is analyzed and the results fall within algorithm specification guidelins developed for the BeyondCare Quality Monitor program.  This means that calibration verification will be verified every 24 hours.  In the "Intended Use" section of the control package inserts, it states that the controls are intended for quality control and calibration verification.  If physical recalibration is necessay, Sysmex technicians will come to the lab and perform the calibration on site.

BCQM supplies the laboratory with a laptop which can be accessed to provide calibration history at any time.  QC and Calibration Verification will be checked by the Supervisor weekly

QUALITY CONTROL PROCEDURE

QC Frequency
Test 3 levels of QC samples once per day of testing using XN-L Commercial Control, manufactured by Streck.

QC Procedure

  • Remove vials from refrigerator and allow them to come to room temperature (18-25oC), for approximately 15 minutes.
  • Mix vials by rolling each vial between the palms of the hands for 15 seconds.
  • Invert each vial by holding the vial at the ends between the thumb and finger.
  • Invert end-over-end using a very quick turning motion of the wrist approximately once a second for one minute.
  • Perform a close visual inspection of each vial confirming the cell button is completely removed from the bottom of the vial and cellular elements are uniformly suspended with no aggregates.
  • Continue inversions as needed to re-suspend the vial contents.
  • Using the mouse, choose manual mode.
  • Barcode the control.
  • Press OK.
  • Place in tube holder and press the transport button.
  1. Check the analysis results in dialog box.
  2. If analyzer displays GREEN, this indicates QC passed and analyzer is ready to process samples. Touch [Accept].
  3. If analyzer displays YELLOW, more information is needed or QC is overdue. The resolve button becomes active if there is a QC value outside of limits.
  4. Resolve is activated: If a QC error has been detected, resolve button becomes active and dynamic troubleshooting prompt guides the end user to the next course of action. The instructions button gives details on how to perform the troubleshooting action.
  5. QC is overdue: End user needs to analyze QC since it exceeds the timeframe from the preferences screen.
  6. If analyzer displays RED, QC failed analysis and analyzer is determined out of service with a reference to a service call.

For a calendar view of whether the QC passed or failed, access the Summary report in the BCQM lap top (from the dashboard icon) which will also display the background status.  Along the bottom of the screen, the codes appearing in the chart boxes will be explained.

New QC Lot crossover or parallel studies

Five days before the last tubes of the current lot expire, the new lot is analyzed two times/day in conjunction with the current QC. The BeyondCare Quality Monitor program establishes the target and limit values for the new QC lot as soon as the first vial of each level gets analyzed.

Reviewing Quality Control Results in BeyondCare Quality Monitor

  • If analyzer displays GREEN, this indicates QC passed and analyzer is ready to process samples.
  • If analyzer displays YELLOW, more information is needed or QC is overdue.
  • More information is needed: If a QC error has been detected, a dynamic  troubleshooting prompt guides the end user to the next course of action. A video display is also a selectable feature.
  • QC is overdue: End user needs to analyze QC since it exceeds the timeframe from the preferences screen.
  • If analyzer displays RED, QC failed analysis and analyzer is determined out of service with a reference to a service call.

Recording and Storage of QC Data

The BeyondCare Quality Monitor application stores the last 2.5 years of QC data on demand. All QC data older than 2.5 years is archived.

Review of QC Data

The following reports will be reviewed biweekly by the Supervisor: Insight Report, Detailed Daily Verification Report, and Continuous Calibration Verification Certificate.

Once these reports have been reviewed through the BeyondCare Quality Monitor application, they can be accessed by going to Activity - Reviewed Documents.
Reports are archived for 2.5 years in BeyondCare Quality Monitor. Reports that are older than 2.5 years can be attained by contacting Sysmex Technical Assistance Center.

 

 

Procedure: 

Start-Up Procedure

1.  Checks prior to turning on:

  • Visual inspections of analyzer / system / reagents
  •        Verify network/host connections are working properly
  •        Verify sufficient reagent supply is nearby.

2. Turning ON the entire system

  • Verify that all power switches for the device are in the ON position
  • Press the Green power buttton on the front on the analyzer to power ON the entire system

3.  Log on to the XN-430 IPU

  • When the logon dialog box appears, enter the user name as 'm145m'.

4.  Analyzer self checks

  • XN-430 :  Initialization of the mechanical parts: Rinse; Temperature stabilizaion; Background Check (up to 3 times)  Background check results are found in  the BCQM laptop.

5.  Analyze Control Material

Patient Sample Processing

  1. Manual Analysis
  • Check the status of the analyzer.  Confirm the analyzer is ready.
  • If the sample tube holder is not ejected, press the sampl tube holder open/close switch
  • Select Manual Analysis button the the control menu.
  • Scan the barcode on the tube or sample ID can be entered maually.
  • Select OK.
  • Properly mix the specimen and place in tube holder
  • Press the switch on the analyzer
  • The tube holder will slide in and the sample will be aspirated
  • When the analysis is complete, the tube holder slides out.
  • Remove the sample, repeat steps for additional samples
  • Review the IPU to determine whether repeat or reflex testing is required.
  • Rerun sample if required.  Make smear if required.

 

             




Test Results

WBC - White Blood Cell or leukocyte count
              LY#          Lymphocyte number
              LY%         Lymphocyte percent (or ratio)
              MO#         Mononuclear cell number
              MO%        Mononuclear cell percent (or ratio)
              EOS#        Eosinophil number  
              EOS %       Eosinophil percent (or ratio)
               BASO#      Basophil number
               BASO %     Basophil percent (or ratio)
               IG#            Immature granulocytes number
               IG%           Immature granulocyte percent (or ratio)
               GR#          Granulocyte number
               GR%         Granulocyte percent (or ratio)
RBC - Red Blood Cell or erythrocyte count
Hgb - Hemoglobin concentration
Hct - Hematocrit (relative volume of erythrocytes)
MCV - Mean Corpuscular (erythrocyte) Volume
MCH - Mean Corpuscular (erythrocyte) Hemoglobin
MCHC - Mean Corpuscular (erythrocyte) Hemoglobin Concentration
Plt - Platelet or thrombocyte count
RDW - Red Cell (erythrocyte volume) Distribution Width
MPV - Mean Platelet (thrombocyte) Volume

Flagged Results

Parameter
Range
Action

WBC, RBC, HGB, PLT

Exceeds linearity

Dilute and re-run

WBC

<4.0 or  >15,000

Slide review

PLT

<100,000  or >500,000

Slide review

MCV

<75 or >105 fl

Slide review

MCHC

> 36

Check for cold agglutinin by placing in 37C incubator for intervals of 15 min; check for lipemia, hemolysis.

RDW

>22%

Slide review

Neut #

<1.0 or >8.0

Slide review

 Neut %

>85%

Slide rev. for bands

Bands, nRBCs

>5%  on slide rev.

Manual differential

Metas, Myelo, Promylocytes, Bands   Manual differential
Eosinophils >10% on slide rev. Manual differential
Basophils >5% on slide rev. Manual differential

Lymph%

> 50.0

Slide review

Mono#

>1.5

Slide review

IG flag   Slide review
Left Shift?   Slide review
Blasts/Abn Lympho?   Slide review - Manual diff if Blasts are seen
Atypical Lympho?   Slide review
NRBC?   Slide review -  If more than 5 NRBC's/100 WBC's - Correct the WBC count See Manual Diff Review

 

Results over range for Plt, WBC, RBC, HGB, HCT GRAN, LYM

 Make a dilution with normal saline

MCV

<50 or >130

Use slide rev to verify - order RBC Morphology and record significant morphology seen.

Reportable Ranges
The Linearity Limit listed below is the range of results over which the Sysmex XN-430 instrument displays, prints and transmits results.  Parameters that exceed these limits are flaggged with @ beside the result.  The sample must be diluted, rerun and multiplied by the dilution factor. Note the use of dilution for linearity on the patient report.

Parameter

Linearity Limit/

Reportable Range

Units

WBC

0.4-440.0

x 103 cells/ mL

RBC

0.02-8.60

x 106 cells/m L

 HGB

0-26.0

g/dL

 PLT

0-999.0

x 103 cells/ mL

Critical Values

Critical/Alert Values are those results demonstrating such variance from normal as torepresent a pathophysiological state with potential of being life threatening unless action is taken quickly. These results must be immediately reported to the care provider and be documented in the test record as to who was contacted, the time of contact, the person making contact, and that the results were read back.

WBCs K/mm3 <3.0 or >15.0
HGB g/dl <8.0 or > 20.0
HCT % <25 or >60
Platelets  K/mm3 <100 or >600

Laboratory Reference Ranges

Parameter

Units

Our Reference Ranges

WBC

x103 cells/ uL

<21 yrs 4.5-13.2

>21 yrs 3.4-10.0

RBC

x106 cells/ uL

Males 4.4-5.9

Females 4.0-5.2

HGB

g/dL

Males 13.5-17.5

Females 12.0-15.5

HCT

ratio

Males 41-53.0

Females 36-46.0

MCV

fL

80.0-100.0

MCH

pg

26.0-34.0

MCHC

g/dL

31.0-36.0

PLT

x103 cells/ uL

140-450

LY

#

<21 yrs 1.0-6.1

>21 yrs 1.0-3.4

MO

#

<21 yrs 0-1.4

>21 yrs 0-0.8

GR

#

<21 yrs 1.8-8.0

>21 yrs 1.8-6.8

EOS x109/L 0-0.24
EOS % 0.2-3.0
BASO x109/L 0-0.2
BASO % 0-1.0

Limitations of the Procedure

 K2EDTA is the recommended anticoagulant. K3EDTA is also acceptable. Use of other anticoagulants can yield misleading results.

 

Interfering Substances

  • Specimens must be free of clots and fibrin strands.
  • Marked changes in plasma constituents (e.g., low sodium, extremely elevated glucose) may cause cells to swell or shrink.  The blood to anticoagulant ratio is important.
  • Red cell fragments, microcytic RBCs or white cell cytoplasmic fragments may interfere with automated platelet counts.
  • Cold agglutinins produce spurious macrocytosis, elevated MCHs, MCHCs, falsely decreased RBC counts and HCTs.  Rare warm agglutinins produce the same spurious results as a cold agglutinin.
  • Extremely elevated WBCs may cause turbidity and falsely increase the hemoglobin, in addition to RBC and HCT values.
  • Severely hemolyzed samples (in vitro) falsely decrease RBC and hematocrit.  Recollect hemolyzed specimens.
  • Giant platelets and clumped platelets may falsely elevate the WBC count and falsely decrease the platelet count.  Platelet clumping and/or "platelet satellitism" can occur in specimens collected in EDTA.  This may falsely elevate the WBC count and falsely decrease the platelet count.   Vortex and reanalyze.
  • Severely icteric samples may falsely elevate the HGB value and related indices.  Make a 1:5 dilution with CELLPACK DCL.
  • Rocking specimen excessively, may affect the WBC differential.
  • Megakaryocytes may falsely increase WBC counts on automated hematology analyzers.

Maintenance

XN-430 Shutdown -performed daily

  • Confirm analyzer and sample unit are at ready
  • If sample tube holder is not ejected, press the sample tube holder open/close switch
  • If any tubes remain in holder, remove.
  • Touch [Menu] on Toolbar.
  • Touch [Shutdown]. Touch [OK]
  •        XN on-board maintenance history will auto-populate Shutdown
  •        IPU will automatically shut off at the conclusion.
  •        Press Green power putton to restart IPU

XN-430 Routine Cleaning - perfomed weekly

CellClean Auto is used to shut down the entire system.  Refer to the XN-L Series Troubleshooting Manual for detailed, illustrated procedures.

  • Confirm analyzer is at ready.
  • Touch the [Maintenance] icon in the Menu screen.
  • Touch [Rinse Instrument].
  • Touch [Routine Cleaning]
  •        If sample tube holder is not ejected, press the sample tube holder open/close  switch and place CELLCLEAN AUTO in tube holder.
  •         Press start switch.
  •         XN-430 on board maintenance will auto-populate Routine Cleaning.

Caution:

  • Use 1 vial of CELLCLEAN AUTO for a single cleaning.  Do not reuse CELLCLEAN AITO that has previously been used
  • During Shurdown, other sample tubes are not accepted.

 

  •  
Key Points: 

 

Use 'XN-530/XN430/XN-330 Basic Operation' or 'Beyond a Better Box Quick Guide' for:

  • How to safely use the analyzer
  •  Getting started and running the instrument day‑to‑day
  • Reviewing unusual results (how to read a result report and what flags mean)
  • Performing  procedures such as cleaning, or replacing a reagent

Use the XN-530/XN-430/XN Troubleshooting for troubleshooting problems with your instrument.

Use 'XN-530/XN-430/XN330 General Information' for:

  • What the instrument does and methods it uses
  • Instrument specifications and requirements

Use 'BeyondCare Quality Monitor User Manual' and the 'Beyondcare Quality Monitor Quick Guide' for understanding the quality assurance program:

  • Access and Login
  • Setup
  • Dashboard
  • Activity Tab
  • Reviewed documents
  • Manage QC
  • Calibration History

References

  1. Sysmex XN-450/XN-430 Automated Hematology Analyzer CLSI Procedure.  Document Number 1235-LSS, Rev. 4, September 2018
  2. Beyondcare Quality Monitor User Manual. Document number: 1346MKT, Rev. 1, June2017